(2R)-2,3-bis(hexadecanoyloxy)propyl 2-(trimethylammonio)ethyl phosphate
L-alpha-Dipalmitoyl phosphatidylcholine
CAS: 63-89-8
Molecular Formula: C40H80NO8P
(2R)-2,3-bis(hexadecanoyloxy)propyl 2-(trimethylammonio)ethyl phosphate - Names and Identifiers
| Name | L-alpha-Dipalmitoyl phosphatidylcholine |
| Synonyms | colfosceril palmitate L-a-Lecitin-dipalmitoyl L-a-Dipalmitoyl Lecithin L-A-LECITHIN DIPALMITOYL L-alpha-Dipalmitoyl phosphatidylcholine 1,2-dipalmitoyl-3-sn-phosphatidylcholine 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOCHOLINE 1,2-Dipalmitoyl-sn-glycero-3-phosphocholine 1,2-dipalmitoyl-L-alpha-phosphatidylcholine L-A-phosphatidylcholine dipalmitoyl*synthetic 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHORYLCHOLINE 1,2-DIHEXADECANOYL-SN-GLYCERO-3-PHOSPHOCHOLINE 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATIDYLCHOLINE 1,2-Dipalmitoyl-sn-glycero-3-phosphocholine monohydrate (R)-2,3-Bis(palMitoyloxy)propyl (2-(triMethylaMMonio)ethyl) phosphate (2R)-2,3-bis(hexadecanoyloxy)propyl 2-(trimethylammonio)ethyl phosphate |
| CAS | 63-89-8 |
| EINECS | 200-567-6 |
| InChI | InChI=1/C40H80NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-39(42)46-36-38(37-48-50(44,45)47-35-34-41(3,4)5)49-40(43)33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h38H,6-37H2,1-5H3/t38-/m1/s1 |
| InChIKey | KILNVBDSWZSGLL-KXQOOQHDSA-N |
(2R)-2,3-bis(hexadecanoyloxy)propyl 2-(trimethylammonio)ethyl phosphate - Physico-chemical Properties
| Molecular Formula | C40H80NO8P |
| Molar Mass | 734.04 |
| Melting Point | 229-229.5 °C |
| Boling Point | 229-229.5℃ |
| Specific Rotation(α) | D23 +6.6° (c = 4.2 in 1:1 chloroform-methanol) |
| Solubility | Chloroform (Slightly), Methanol (Slightly) |
| Appearance | Form Solid, color White to Off-White |
| Color | White to Off-White |
| Merck | 14,2477 |
| Storage Condition | -20°C |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Physical and Chemical Properties | Chemical properties Monohydrate: Crystallization from thermal diisobutanone. Softened at 75~79 ℃. [α]D23 6.6. (C = 4.2,1:1 chloroform-methanol). Easily soluble in chloroform, hot diisobutanone or hot dioxane. Easily emulsified in water. Solubility at 22-23 ℃ (g/100ml): ethanol 1.5, ether 0.02, acetone 0.02, pyridine 1.1, acetic acid 4.0, methanol 1.4. |
| Use | The application is natural surface active substance, which is the main component of exogenous surface active substance preparation. It is used to rescue newborns with a birth weight of 700g or more who are mechanically ventilated for RDS. |
(2R)-2,3-bis(hexadecanoyloxy)propyl 2-(trimethylammonio)ethyl phosphate - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10-21 |
| HS Code | 29232000 |
(2R)-2,3-bis(hexadecanoyloxy)propyl 2-(trimethylammonio)ethyl phosphate - Upstream Downstream Industry
(2R)-2,3-bis(hexadecanoyloxy)propyl 2-(trimethylammonio)ethyl phosphate - Reference
| Reference Show more | 1. [IF=6.953] Jun Meng et al."Coating function and stabilizing effects of surface layer protein from Lactobacillus acidophilus ATCC 4356 on liposomes."Int J Biol Macromol. 2021 Jul;183:457 2. [IF=6.057] Qian Liu et al."A novel electrochemical aptasensor for exosomes determination and release based on specific host-guest interactions between cucurbit [7]uril and ferrocene."Talanta. 2021 Sep;232:122451 |
(2R)-2,3-bis(hexadecanoyloxy)propyl 2-(trimethylammonio)ethyl phosphate - Nature
| specific rotation | D23 6.6° (c = 4.2 in 1:1 chloroform-methanol) |
| Solubility | Chloroform (Slightly), Methanol (Slightly) |
Last Update：2024-04-10 22:29:15
(2R)-2,3-bis(hexadecanoyloxy)propyl 2-(trimethylammonio)ethyl phosphate - Uses and synthesis methods
biological activity
DPPC (129Y83) is a phosphoglyceride that can be used to prepare liposome monolayers. DPPC-liposome can be effectively used as a delivery vehicle for the induction of immune responses against GSL antigens in mice.
Target
Human Endogenous Metabolite
Production method
Synthetic surfactant, composed of palmitchphos plus decane alcohol and telosapor (Tyloxapo1).
Last Update：2024-04-09 21:21:28
(2R)-2,3-bis(hexadecanoyloxy)propyl 2-(trimethylammonio)ethyl phosphate - Reference Information
| biological activity | DPPC (129Y83) is a phosphoglyceride that can be used to prepare liposomes Monolayer. DPPC-liposome can be effectively used as a delivery vehicle for the induction of immune responses against GSL antigens in mice. |
| target | Human Endogenous Metabolite |
| chemical properties | monohydrate: crystallized from hot diisobutanone. Softened at 75~79 ℃. [α]D23 6.6. (C = 4.2,1:1 chloroform-methanol). Easily soluble in chloroform, hot diisobutanone or hot dioxane. Easily emulsified in water. Solubility at 22-23 ℃ (g/100ml): ethanol 1.5, ether 0.02, acetone 0.02, pyridine 1.1, acetic acid 4.0, methanol 1.4. |
| use | is a natural surface active substance and is the main component of exogenous surface active substance preparation. It is used to rescue newborns with a birth weight of 700g or more who are mechanically ventilated for RDS. |
| production method | synthetic surfactant, composed of palmnchphos plus decadecyl alcohol and Tyrosapor (Tyloxapo1) composition. |
Last Update：2024-04-09 21:11:58
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View History
(2R)-2,3-bis(hexadecanoyloxy)propyl 2-(trimethylammonio)ethyl phosphate
D-2-CYCLOHEXYLGLYCINE METHYL ESTER HYDROCHLORIDE
71776-05-1
3-甲氧基异噁唑-5-羧酸
932-67-2
1-(4-IODOPHENYL)ETHANONE
peperonal
Methotrexate Impurity 21
乙二胺水合物
2-羟基-1-萘(甲)醛
D-2-CYCLOHEXYLGLYCINE METHYL ESTER HYDROCHLORIDE
71776-05-1
3-甲氧基异噁唑-5-羧酸
932-67-2
1-(4-IODOPHENYL)ETHANONE
peperonal
Methotrexate Impurity 21
乙二胺水合物
2-羟基-1-萘(甲)醛
Raw Materials for (2R)-2,3-bis(hexadecanoyloxy)propyl 2-(trimethylammonio)ethyl phosphate
TYLOXAPOL
Hexadecanoic acid, 1,1'-[1-[[(2-oxido-1,3,2-dioxaphospholan-2-yl)oxy]methyl]-1,2-ethanediyl] ester
Choline glycerophosphate
1,2-DIPALMITOYL-SN-GLYCEROL
Palmitic acid
Trimethylamine
Hexadecanoic acid, 1,1'-[1-[[(2-oxido-1,3,2-dioxaphospholan-2-yl)oxy]methyl]-1,2-ethanediyl] ester
Choline glycerophosphate
1,2-DIPALMITOYL-SN-GLYCEROL
Palmitic acid
Trimethylamine